Stopping wound bleeding
Before a surgeon starts the actual operation, he or she must "seal" the opening in the body caused by the surgical wound. One possibility for doing this is to use a fibrin sealant. This substance is used to stop bleeding and seal the wound edges.

Thanks to recent developments in this area, a two-component adhesive can now be applied with a kind of hypodermic. Sport Orthopedics Bern uses the tissue sealant Tissucol, a biological two-component adhesive, for this purpose. One component contains mainly (human) fibrinogen and small amounts of plasma fibronectin, factor XIII, plasminogen and the plasmin inhibitor aprotinin (of bovine origin). The second component is human thrombin.

The actual adhesive is manufactured from plasma and causes blood coagulation.

Tissucol is manufactured from human plasma. The plasma used to produce Tissucol is quality-controlled by the Hyland Immuno Quality Assurance System (HIQS). When the product is applied, the fibrinogen is converted to fibrin by the thrombin. This reaction corresponds to the last step in physiological plasmatic blood coagulation. The fibrin produced in this way is used to stop bleeding (hemostasis) and seal wounds in gastroenterology and all branches of surgery

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Baxter A - partner of Sport Orthopedics Bern for surgical treatments: Baxter Healthcare Corporation You can find comprehensive information on fibrin sealants and Tissucol at: http://www.tissuesealing.com